Tampilkan postingan dengan label medicine. Tampilkan semua postingan
Tampilkan postingan dengan label medicine. Tampilkan semua postingan

Selasa, 06 Desember 2011

A 3-D Printer Makes Human Bones


We’re already printing organs to order, so why not Cmd+P some customized 3-D bone? Washington State University researchers have tweaked a 3-D rapid prototyper designed to create metal parts to print in a bone-like material that acts as a scaffold for new bone cells. In just a few years, the researchers say, doctors and dentists could be printing up custom bone tissue to order.

Reported in the journal Dental Materials, the bone-like material appears to cause no negative side effects and eventually dissolves. But before doing so, it serves as a scaffold for new bone cells. Placed in a medium of immature human bone cells, the printed structures encourage the growth of new bone that fuses with existing bone tissue.

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"If a doctor has a CT scan of a defect, we can convert it to a CAD file and make the scaffold according to the defect,” Susmita Bose, co-author and professor in WSU’s School of Mechanical and Materials Engineering, said in a press release.


In terms of potential for regenerative medicine, that’s fairly huge. It opens the door to the ability to create perfect--or nearly perfect--replacement implants for damaged or deformed bone tissue and grow new, corrective bone that is the real thing rather than a ceramic or metal analog. And the procedure is relatively fast. Networks of new bone cells reportedly grew within the 3-D printed structures within just a week of placing them in a culture with immature bone cells.

Kamis, 15 September 2011

Creating inorganic life?



Scientists in Scotland are undertaking pioneering research to create life from inorganic chemicals.

All life on earth is based on organic biology - in the form of carbon compounds - but the inorganic world is considered to be inanimate.

A team from Glasgow University has demonstrated a new way of making inorganic chemical cells.
The aim is to create self-replicating, evolving inorganic cells which could be used in medicine and chemistry.
The project is being led by Professor Lee Cronin from the university's College of Science and Engineering.

Useful applications
 
He said: "What we are trying do is create self-replicating, evolving, inorganic cells that would essentially be alive. You could call it inorganic biology." 

Professor Cronin's team has demonstrated a new way of creating inorganic chemical cells.
These can be compartmentalised by creating internal membranes that control the passage of materials and energy through them, meaning several chemical processes can be isolated within the same cell - just like biological cells.

Researchers say the cells, which can also store electricity, could potentially be used in all sorts of applications in medicine, as sensors or to confine chemical reactions. 

The research is part of a project by Prof Cronin to demonstrate that inorganic chemical compounds are capable of self-replicating and evolving - just as organic, biological carbon-based cells do.
Prof Cronin believes that creating inorganic life it is entirely feasible.

He added: "The grand aim is to construct complex chemical cells with life-like properties that could help us understand how life emerged and also to use this approach to define a new technology based upon evolution in the material world - a kind of inorganic living technology. 

"Bacteria are essentially single-cell micro-organisms made from organic chemicals, so why can't we make micro-organisms from inorganic chemicals and allow them to evolve? 

"If successful this would give us some incredible insights into evolution and show that it's not just a biological process. It would also mean that we would have proven that non carbon-based life could exist and totally redefine our ideas of design."

 by "environment clean generations"


Minggu, 04 September 2011

Bio-Inspired Design is Reshaping the Future



From harvesting energy to building networks, nature has been solving problems for billions of years longer than humans have.

How exactly does one turn sunlight and water into usable energy? If it were possible to ask any living organism on Earth this question, you could do far better than asking a biologist or a chemist, or any other human being for that matter, and take the question directly to a leaf. That’s the goal of biomimicry: to take human problems and ask nature “how would you solve this?” And increasingly, such questions are changing everything, from energy to information technology to the way we build cities.
To see how a leaf works its magic, look no further than Dr. Daniel Nocera’s lab at MIT. Yesterday, Nocera’s team announced that it has created the first practical "artificial leaf", a synthetic silicon device that splits water into oxygen and hydrogen for fuel cells using sunlight just as a natural leaf does. Nocera’s leaf isn’t a perfect mimic of photosynthesis--for instance, it requires materials like nickel and cobalt that must be extracted from the earth, and catalysts that spur reactions that otherwise wouldn’t happen on their own. But it’s indicative of a growing shift in how humans solve big problems by looking to nature for elegant solutions rather than bending the natural world to their wills.

With its 4.5-billion-year head start on mankind, the natural world has developed some clever mechanisms for solving big problems, and that natural cleverness isn’t just informing new ways to generate energy. It’s slowly but surely informing everything from the the way emergency rooms are designed to how data networks communicate. It asks that electricity grids act like bees and businesses manage resources like coral reefs manage calories. Seriously.


“Biomimicry is a beautiful way of framing the design process to be cognizant of how nature does things,” says Dr. John Warner of the Warner Babcock Institute for Green Chemistry. “I think that over the centuries humans have become a little egotistical in trying to bend materials and things to our will.”


Warner and his colleagues are on the science side of biomimicry’s collaboration between biology and design. As a green chemist, he and his lab develop new environmentally benign materials often borrowing from natural processes along the way. In Warner’s world, gone are the heat, high pressures, and toxic additives native to much man-made chemistry, replaced with processes that hew more closely to the way nature creates materials.

 On the other side of that equation are the engineers looking for new and better materials with which to design. And increasingly there’s a stronger dialogue between the two, driven partially by an increased environmental consciousness but moreso by a pressing imperative to solve big, overarching problems at the macro scale. 


Take Nocera’s leaf for instance: in light of an always-looming global energy (and environmental) crisis, a means to generate electricity from plentiful (and renewable) water and sunlight could solve a number of huge problems, both natural and man made. The answer is right there in the leaf, and has been for millennia--unlock that natural mechanism in a feasible, economically viable manner and you’ve got a beautiful solution to problems ranging from the environmental to the humanitarian to the geopolitical.

 “When you think about the natural world, nature outperforms us in its diversity, in its complexity, but does so at ambient temperature, at low pressures, using water for the most part as a solvent.” Warner says. By helping humans to think more like a leaf (or an ant hill, or a 1,200-year-old oak, or a bacterial colony), biomimicry is tapping that multi-billion-year head start to bring the same kind of complexity and diversity to human invention. 

Materials: Rewriting the Story of Stuff

“Biomimetic materials have the potential to rewrite our story of stuff,” says Tim McGee, Senior Biologist at the Biomimicry Group. “For most of the materials we use today we’re mining either ore or oil, we transport them, we heat them, we machine them and then they usually have products baked into them that are slightly toxic or not benign. That’s completely different than the way natural systems use materials.” 


Nature, McGee says, uses materials that are readily available nearby and does so in a way that when they’re no longer needed they can be broken down into their component parts and used again. It’s not a novel concept. New York-based Ecovative “grows” packaging materials, plastics (living polymers), and building insulation from things like mycelia (basically mushroom roots). The industrial input: agricultural byproducts like buckwheat husks and cotton seed hulls--no harsh chemicals, no global supply chain of raw materials (pictured are Eben Bayer [left] and Gavin McIntyre of Ecovative with their mushroom-based material).


By looking to ecosystems as a model, we could reorganize our entire supply chain of “stuff” by using biomimetic materials that are sourced locally and manipulated into essentially whatever we want them to be without harsh chemical processes. How? McGee sees huge potential in tweaking 3-D printing tech to be more bio-friendly. “Right now rapid 3-D printing uses these plastics and metals and other things we already know how to work with,” he says. “I think biomimicry could completely change that story by having those rapid prototyping materials be bio-inspired and really perform in a way that we’ve never seen materials perform.”

Building: Cities That Work Like Ecosystems

 

Nature provides a blueprint for smart, efficient systems that has been largely overlooked or ignored by those who organize our population centers. There is plenty to be considered in the way certain coastal oaks gird themselves against hurricane winds or in the way desert plants make the most efficient use of scarce rainfall, but those are piecemeal solutions to individual problems. McGee is more interested in the wholesale re-imagining of the modern burg via “generous cities” that don’t just feed off their environments, but instead give back to their surroundings.


“Imagine a city where the water leaving the city is cleaner than that coming in, or a city that literally breathers carbon dioxide in to make products,” McGee says. “Or imagine if a city actually increases the biodiversity of a region or facilitates that happening in some way. All of that is possible, and people are working on it.”


Look no further than Calera, a California company that is successfully sequestering carbon dioxide in concrete by emulating sea coral. Rather than heating limestone to create concrete (and lots of carbon dioxide), Calera is mixing mineral rich seawater with power plant emissions in a process that causes the calcium in the water to bond with the carbon in the emissions to form cement. The emissions from the power plant are thus sequestered in the concrete that growing cities are built from (Calera's Moss Landing, Calif., pilot plant is pictured).

Economics: Moving Resources Like Coral Reef Calories

 

Economists of a certain stripe point proudly to free markets as the most efficient allocators of resources. A biologist studying how calories move through coral reefs or the complex energy cycles of African savanna ecosystems might tell you that waste is far less prevalent in natural systems that maximize nearly every bit of energy. By simply observing food webs it’s easy to see that complexity doesn’t always breed inefficiencies, and that systems that waste not, want not.


McGee is particularly interested in this kind of systems-level bio-inspiration, because it has less to do with creating something new and more with re-thinking how things like businesses and larger economic networks are organized. “Drawing inspiration from natural systems can help us rethink or re-imagine our existing systems,” McGee says. “And I think that actually can have quite an impact pretty rapidly. It’s about how you organize things, so you don’t need materials or development time. You can put it into place pretty rapidly.”

Health: Battling Bacteria with Biomimicry

 

Medicine and biology are by nature already tightly intertwined, and there are numberless examples of medical researchers repurposing natural processes in really crafty ways to create everything from better glues for patching bones to proteins that can potentially treat blindness.


But perhaps more exciting than bio-inspired treatments are some of the clever natural mechanisms being leveraged to keep pathogens and injuries at bay. For instance, Florida-based Sharklet Technologies realized that shark skin possesses a unique texture that doesn’t allow bacteria and other organism to take hold. By duplicating this unique pattern on an adhesive synthetic sheet, Sharklet has created a bacteria-free surface that can be used in hospitals, restaurants, and other places where contamination has consequences.


What’s more, because this technique doesn’t kill bacteria it will be far more difficult for them to evolve a resistance to it, sidestepping the core problem with most attempts at rendering bacteria harmless. After all, the root technology underwent a 400-million-year incubation period in the ocean, and bacteria haven't figured out how to thwart it yet.

Energy: Nature Already has a Smart Grid

 

Devising a practical and efficient means of harnessing photosynthesis is quite possibly THE Holy Grail of energy research, but it's not the only way biomimicry has the potential to change the global energy paradigm. Biomimicry has the potential to rewire the entire world for cheap and abundant energy by informing the design of smart grids and other energy infrastructure.


One company is doing so not by looking to plants, but to insects like ants and bees. Toronto-based Regen Energy has been exploring “swarm logic” for several years now, developing software based on the working principles an insect swarm--that is, that each individual node in the system doesn’t need a direct order from the leader to act in a way that maximizes benefit to the entire network.


By mimicking swarm intelligence, the company has already developed a means to manage energy networks like the HVAC systems in large buildings to reduce peak electrical demand. And just a few weeks ago Regen announced that the Los Angeles Department of Water & Power is considering tapping swarm logic to help manage its DOE-funded Smart Grid EV integration project, bringing hive mentality to one of America’s largest public utilities.

Information Technology: Mimicking Natural Networks

 

Ants and bees aren’t just informing energy grids. “Some of the early successes in biomimicry already have come from millions of dollars saved by mimicking how an ant communicates information and translating that into how you send server packets over the Web or how you pick a route for your trucks to drive or something like that,” McGee says. 


There’s plenty more to learn; researchers at Pacific Northwest National Laboratory have developed a computer network security system based on the swarm intelligence ants use to defend their hills, and going all the way back to 2007 researchers inspired by honeybee communications built a system that lets networks optimize performance by taking advantage of idle servers during periods of high demand. But McGee thinks we’ve just scratched the surface of what biology can do for IT.


“We’ve already seen an explosion in the relationship between understanding biology using information sciences and then developing ideas in information sciences based on biological insight,” he says. “I think there’s still a lot of room there to play with computer science and biology by learning from biological systems.”

 by "environment clean generations"