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Tampilkan postingan dengan label brain. Tampilkan semua postingan

Senin, 05 Desember 2011

Love, Sex and Brain Development in Adolescence


Teen romance and the possibility of sex...It is one of the trickiest and difficult topics that we, as parents, talk to our kids about. Making sure your teenager has good information and a healthy attitude about opposite sex relationships is a challenging parental responsibility. We know that our teenagers are going to parties, hanging out together, sometimes drinking and some are having sex.
According to a 2005 Statistics Canada report:
o About 12% of teens have had sexual intercourse by age 15 and by the time they reach the age of 17, 28% teens have. By age 24, 80% of young adults have had sexual intercourse.
o Of the sexually active youth between age 15 and 24, over one third of them had more than one partner in a year and 30% did not use a condom the last time they had intercourse.
o Teen pregnancy has been steadily decreasing over the past 25 years. However the number of teens who have contracted sexually transmitted diseases (STDs) such as Chlamydia remains on the rise. This points to reduced use of condoms or the prevalence of oral sex which many teens mistakenly believe eliminates the transmission of STDs.


So, as parents, what sort of influence do we have? According to a 2005 University of Regina in Saskatchewan study, teachers emerged as the most important source for information about pregnancy and STD prevention. The study also found that peer influence was more important than parental disapproval in predicting whether a student would have intercourse. The findings suggest that, teachers and peers are more important in providing good information and instilling attitudes to our teenagers than parents. Parental disapproval has little impact. In fact parental disapproval often has the opposite effect one is trying to accomplish.

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Romance and the Teenage Brain

The conflict between young love and parental disapproval is not a new one. In Shakespeare's Romeo and Juliette, his "star crossed lovers" showed what havoc teen romance can have on families. Today, perhaps it is understandable and acceptable for school to be a more important source of information than parents on certain information about sex. However, most of us hope our values are important to our children and help guide their sexual behaviour choices.
When your son or daughter has fallen in love the personality change may seem extreme. It like they have been invaded by an alien body snatcher. The power of teen love and sex is very strong. Many parents feel responsible for their teenager's risky behavior and become overwhelmed with feelings of guilt. Parents and especially mothers often feel the judgment of other parents whose teen's behaviour is less extreme This can lead to additional feelings of isolation and ineffectiveness. Some parents and especially fathers may get authoritative out of frustration and eventually give up or "wash their hands" of the problem out of feelings of ineptitude.

To be more influential it helps to equipped with the knowledge of what forces are at work when a teenager falls in love. It is important to understand how the teen brain works. Recent brain scientific research sheds much more light on how much hormonal activity is influencing our teenager's thoughts and actions.
Brain structures and brain chemicals both affect the way an adolescent first dives into romance. In his book Why Do They Act That Way?: A Survival Guide to the Adolescent Brain for You and Your Teen, David Walsh describes it this way. At around age ten, the body produces androgen hormones. This is when the first crush can occur. It is at puberty when the real awakening of sexual interest and sex drive occurs. This is when "falling in love" can happen. The hypothalamus drives surges of testosterone in both boys and girls and raises the levels of dopamine - the hormone that is responsible for feelings of pleasure. Because of developmental differences, boys and girls have different attitudes toward sex and romance. The testosterone surges in boys lead them to see girls as sexual objects. Adolescent girls tend to be more drawn to boys for the relational aspects of spending time together and talking.

Although sexual interest is always part of falling in love, falling in love is not always part of sex drive. The prefrontal cortex (the place of reason and judgment in the brain) is inactive and in teenagers not yet fully developed. When falling in love, we aren't using our rational brain and impulse control. A "pleasure" high comes from the hormonal interplay of dopamine, norepinephrine, and serotonin. It is a powerful mix of natural neurological "chemistry". All this high level of hormonal fireworks cannot be sustained for a long time by the brain. The intense feelings of "falling in love" are even shorter for teenagers than adults. Infatuation lasts only about three months on average. Following this they will move on to another relationship for the intoxication and excitement or will stay as the relationship transitions into a calmer more comfortable stable state, which has been called "standing in love".

During the "standing in love" phase cooling down occurs and the prefrontal cortex engages. The teen is in a better position to assess the suitability of the relationship. The adolescent may wonder, "Why am I in this relationship?" A different set of hormones are released now. For girls it is oxytocin sometimes referred to as the "cuddling" hormone, also involved at childbirth, which promotes attachment. In boys, the hormone vasopressin makes them more protective, faithful and attentive to their partner's needs.

 Romantic Pitfalls Often parents worry about their child falling in love with a "bad apple". Concern about a teenager's judgment is warranted. The prefrontal cortex is not completing formed in the brain until age 21. In this stupor of love, the bad influence of the boyfriend or girlfriend leads the "good" child to do things quite out of character. For example they may engage in some risky behavior out of loyalty and love such as destroy property for the "rush" of it.



Sometimes the darker side of love of jealousy and possessiveness takes hold. It is confusing for many teenagers. After the glorious "falling in love" feelings and then attachment hormones can cloud the judgement. He can become controlling, or physically or sexually abusive. When the "why am I in this relationship? question comes to mind, her memories of the "falling in love" times and the current cuddling hormone and lack of experience make it more difficult to see the wisdom of getting out.

Tips for Talking to Teens about Sex Countries with low rates of teen pregnancy and STDs deal with sex more openly. If trusted adults, teachers and parents don't talk openly, the adolescents will get their information from peers or the media. It is important to distinguish sex from sexuality. Sex is about biology whereas sexuality is about biology, psychology, values and spirituality. It is important for you to see your role as supplementing the logic, wisdom and judgement that the teen's under developed prefrontal cortex requires. Actively listening, validating feelings and show respect will help open up discussions and reduce power struggles.
David Walsh in his book Why Do They Act That Way?, suggests the following tips and do's and don'ts.

1. Get motivated. If you do not talk to them someone else will.
2. Get educated. Being informed overcomes nervousness and builds confidence
3. Get comfortable. It is ok to admit some discomfort. It will help everyone relax.
4. Make it an ongoing conversation.
5. Don't try to cover too much in one discussion.
6. Choose appropriate times when there is an opportunity for calm, private uninterrupted conversation
7. Discuss sexuality, not just sex. They need to know about the place of sex in a healthy relationship.
8. Discuss dating as a time to have fun and get to know each other.
9. Don't preach or lecture.
10. Make it a dialogue
11. Share your values

Do
o Emphasize the importance of respect and honesty in all relationships
o Have regular conversations with your sons and daughters about sex and sexuality
o Communicate the values you consider important in romantic relationships
o Provide accurate information about birth control and STDs
o Get to know your adolescent's friends so you know who they are influenced by
o Really listen to your teen: their fears, and worries and validate their feelings showing acceptance and love
o Talk to other parents, join a parents group, see a counselor for ideas and support

Don't
o Don't get angry or use put-downs about a boyfriend or girlfriend you have concerns about
o Don't ridicule or make fun of crushes or romantic attachments
o Don't assume that your son or daughter won't engage in sexual behavior
o Don't keep quiet and let the "instant sex" that happens on TV and in movies become the only examples your kids have about sex and sexuality Allan Findlay M.S.W. is a Toronto based Marriage and Family Therapist. He is a Registered Clinical Social Worker with extensive experience helping couples and families for over 25 years restore respect and rebuild trust.

For couples in crisis in the aftermath of an extra-marital affair, or for those who are drifting apart, couples benefit from Allan's structured counseling approach. His therapy de-escalates negative interactions and establishes new patterns that promote secure emotional attachments in adult relationships. Trust is rebuilt, problems solved, partnership strengthened, and intimacy restored.
For parents whose teenagers are uncommunicative, disrespectful, defiant, or are abusing drugs or alcohol, families come to Allan before it is necessary to kick their teen out of home. His extensive knowledge of the psychological development of teenagers, his gentle but firm style and structured approach de-escalates conflict and restores respectful relationships between all family members.
Environment Clean Generations

Rabu, 05 Oktober 2011

Molecules that Could Erase or Restore Memory


A picture of the past, a memory of a nice afternoon, sitting on the grass doing homework with someone you love. An image or a movie takes up space on a computer's hard drive, so what causes the reactions to store these memories in our mind? Let's take a look at a couple of recently discovered molecules that might be able to impact human memory in the coming decades. 

Our Understanding of Memory is still in its Infancy
Memories form because of interactions between several parts of the brain, with learning arising from the changes in neuron synapses. 

We are still in the infancy of knowing exactly how a memory is formed and subsequently altered, with most conclusions coming from trial and error observations involving hormones.



For example, injections of cortisol, a steroid hormone released by the adrenal gland in response to stress, and adrenaline into subjects have been shown to increase the retention of short term memory.

Long-term stress situations, however, which would allow for streams of cortisol to be present, have be shown to hamper short term memory (with this showing that there is a delicate chemical balance in place to separate remembering and forgetting). 

Additional work has looked at cell signaling and neurotransmitters, like dopamine, and what regions of the brain are populated by specific neurotransmitters.

Protecting our Memories
 
Using the small molecule P7C3, first mentioned in the journal article Discovery of a Pro-neurogenic, Neuroprotective Chemical, is a possibly way in which to aid in restoring memories. P7C3, due to its neuroprotective properties, could be used to ward off the later stages of Alzheimer's by aiding in the branching of neurons and protecting neurons from being degraded.

Exactly how P7C3 works, however, is not known. P7C3 and a more potent analogue, were discovered through a screen of over 1,000 individual molecules through in vivo assays. This is quite the "shotgun" approach, throwing a lot of previously synthesized molecules at a problem and seeing if any work. This is a common method used in drug discovery, and also shows that there is no "one" good way to design a memory enhancing molecule. Yet.

Can we Erase Bad Memories?
 
When the amount of the large molecule CaMKII (to give an idea of scale of CaMKII, it is about one thousand times larger than cortisol or P7C3) is spiked within in the brain of a mouse, the recall of a short term memory associated with fear decreases. 

That's according to research reported in the journal article Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation
However, as with stress induced cortisol release, too much CaMKII can lead to the impaired ability to recall memories, and extending past cortisol, the erasure of new and fear-induced memories specifically without harming other memories.

 These experiments were only performed in mice, so implementation in humans might be years away or not possible at all, but it gives hope for research looking to radically change the memories on an individual for positive reasons.
CaMKII is also for sale as a reagent, increasing the accessibility and thus ease of research. It's not cheap, however, and if you do try to use it, it's not likely to be administered properly, so don't run out and buy it to black out your memories of the monsters that did live under your bed.

CaMKII release has recently been shown to be extremely specific and activated in the formation of dendritic spines, lending insight into how the molecule behaves and putting a bit of theory behind the molecule's ability to significantly alter neurochemistry enough to block memories.

If you play with your memories, are you changing who you are?
 
Would you want to erase a bad memory? In situations of physical abuse or harm, yeah, more than likely. But what about that test you failed or your first break-up? That time you drove home with the lights on in your car after watching a scary movie? These are the moments that help make us who we are, and in sum, condition us to change our decision-making in the future.

 So before we go around erasing memories, we probably want to make sure we are erasing the right types. For example, if all memories of a certain type (like those pertaining to fear) were erased, we would probably have to spend time acclimating ourselves to our environment and possibly remembering why we don't put our hand on a hot stove. Further research to help us learn the mechanism for how the molecules work couldn't hurt either.

by "environment clean generations"



Selasa, 04 Oktober 2011

What Happens in the Brain During an Orgasm?


Although the reasons for having sex of any kind are varied and complex, reaching orgasm is usually the goal. Because we're all so different, coming up with a universal description of an orgasm is impossible. The one thing that most people can agree on is that it's an incredibly, intensely pleasurable experience.


So what is it? When in doubt, go to the dictionary. The Oxford English Dictonary defines an orgasm as "a sudden movement, spasm, contraction, or convulsion [...] a surge of sexual excitement." Merriam-Webster gets more descriptive, stating that it's "an explosive discharge of neuromuscular tensions at the height of sexual arousal that is usually accompanied by the ejaculation of semen in the male and by vaginal contractions in the female." The famous sex researcher Dr. Alfred Kinsey once said that an orgasm "can be likened to the crescendo, climax, and sudden stillness achieved by an orchestra of human emotions ... an explosion of tensions, and to sneezing" [source: Geddes].

Dr. ­Kinsey's comparison to sneezing might be debatable, but other than that, all of these definitions are basically correct. They're just a few of the many different attempts to describe exactly what it means to have an orgasm.


Nearly every aspect of the orgasm -- what's required to have one, why some people can't seem to achieve one, why we have them at all -- has been the subject of much research and debate. What happens to the body during an orgasm is pretty well-known, and it's no surprise that the brain plays a big part in reaching one. But researchers are still in the process of figuring out exactly what's happening in the brain during an orgasm. Let's start with looking at the messages that the body sends to the brain.

Without nerves sending impulses back to the spinal cord and brain, an orgasm wouldn't be possible. Just like any other area of the body, the genitalia contain different nerves that send information to the brain to tell it about the sensation that's being experienced. This helps to explain why the sensations are perceived differently depending on where someone is being touched. A clitoral orgasm, for example, differs from a vaginal orgasm because different sets of nerves are involved.

All of the genitalia contain a huge number of nerve endings (the clitoris alone has more than 8,000 of them), which are, in turn, connected to large nerves that run up through the body to the spinal cord. (The exception is the vagus nerve, which bypasses the spinal cord.) They perform many other functions in the body in addition to providing the nerve supply, and therefore feedback to the brain, during sexual stimulation. Here are the nerves and their corresponding genital areas
  • hypogastric nerve - transmits from the uterus and the cervix in women and from the prostate in men
  • pelvic nerve - transmits from the vagina and cervix in women and from the rectum in both sexes
  • pudendal nerve - transmits from the clitoris in women and from the scrotum and penis in men
  • vagus nerve - transmits from the cervix, uterus and vagina


The role of the vagus nerve in orgasms is a new discovery and there's still much that's unknown about it; until recently, researchers didn't know that it passed through the pelvic region at all.
Since most of those nerves are associated with the spinal cord, it would stand to reason that a person with a severed spinal cord wouldn't be able to have an orgasm. And for a very long time, that's what people with these types of injuries were told. 

However, recent studies show that people with spinal cord injuries -- even parapalegics -- can reach orgasm. Dr. Barry Komisaruk and Dr. Beverly Whipple of Rutgers University conducted a study on women with severed spinal cords in 2004. 


They discovered that these women could feel stimulation of their cervixes and even reach orgasm, although there was no way their brain could be receiving information from the hypogastric or pelvic nerves. How was this possible? An MRI scan of the women's brains showed that the region corresponding to signals from the vagus nerve was active. Because the vagus bypasses the spinal cord, the women were still able to feel cervical stimulation.

So during sexual stimulation and orgasm, different areas of the brain receive all of this information that lets it know exactly what's happening -- and that what's happening is very enjoyable. But until recently, we had no way of knowing exactly what was happening in the brain at the exact moment of orgasm.

Pleasure Center of the Brain: Light It Up

You may have heard that the brain has a pleasure center that lets us know when something is enjoyable and reinforces the desire for us to perform the same pleasurable action again. This is also called the reward circuit, which includes all kinds of pleasure, from sex to laughter to certain types of drug use. Some of the brain areas impacted by pleasure include:
  • amygdala - regulates emotions
  • nucleus accumbens - controls the release of dopamine
  • ventral tegmental area (VTA) - actually releases the dopamine
  • cerebellum - controls muscle function
  • pituitary gland - releases beta-endorphins, which decrease pain; oxytocin, which increases feelings of trust; and vasopressin, which increases bonding

 
Although scientists have long been studying the pleasure center, there hadn't been much research about how it relates to sexual pleasure, especially in women. In the late 1990s and the mid-2000s, a team of scientists at the University of Groningen in the Netherlands conducted several studies of both men and women to determine brain activity during sexual stimulation. The team used PET scans to illustrate the different areas of the brain that would light up and shut off during sexual activity. In all of the tests, the subjects were scanned while resting, while being sexually stimulated and while having an orgasm.

Interestingly, they discovered that there aren't too many differences between men's and women's brains when it comes to sex. In both, the brain region behind the left eye, called the lateral orbitofrontal cortex, shuts down during orgasm. Janniko R. Georgiadis, one of the researchers, said, "It's the seat of reason and behavioral control. But when you have an orgasm, you lose control" [source: LA Times]. Dr. Gert Holstege stated that the brain during an orgasm looks much like the brain of a person taking heroin. He stated that "95 percent is the same" [source: Science News].

There are some differences, however. When a woman has sex, a part of the brain stem called the periaqueductal gray (PAG) is activated. The PAG controls the "flight or fight" response. Women's brains also showed decreased activity in the amygdala and hippocampus, which deal with fear and anxiety. The team theorized that these differences existed because women have more of a need to feel safe and relaxed in order to enjoy sex. In addition, the area of the cortex associated with pain was activated in women, which shows that there is a distinct connection between pain and pleasure.

The studies also showed that although women m­ay be able to fool their partners into thinking they've had an orgasm, their brains show the truth. When asked to fake an orgasm, the women's brain activity increased in the cerebellum and other areas related to controlling movement. The scans didn't show the same brain activity of a woman during an actual orgasm.
But what about people who can't reach orgasm at all?

Neither Here Nor There: Anorgasmia and Non-genital Orgasms

I­n some cases, we know what causes anorgasmia (the inability to reach orgasm). Drugs like Celexa, Zoloft and Paxil -- known as SSRIs, or selective seratonin reuptake inhibitors -- are often used to treat depression, anxiety and other mental illnesses. Like most drugs, however, they can have side effects. For some people, this includes sexual ones, including anorgasmia.


But why? SSRIs can decrease the brain's production of dopamine, the neurotransmitter that provides pleasurable feelings and reinforces a person's desire to once again perform the action that brought him or her pleasure. Sometimes the problem goes away on its own, or it can be resolved by switching to a different antidepressant or taking another drug in addition to the SSRI. However, a small number of people experience post-SSRI sexual dysfunction (PSSD) that lasts for days, weeks, months or even years after discontinuing use of an SSRI. The cause of this dysfunction isn't understood, as stopping the SSRI allows dopamine production to return to normal.

The Dutch studies about orgasms (mentioned earlier), along with others, have also been the basis for continuing research in helping women who are anorgasmic. Dr. Barry Komisaruk at Rutgers University is currently studying women who are anorgasmic and women who are constantly aroused sexually but are unable to reach orgasm. The latter group of women were each put in an MRI scanner where they could see their brain activity on a monitor. Their brain scans showed that the brain thought they were in fact constantly being sexually stimulated. The women then used imagery and other neurofeedback exercises to calm their brains. Dr. Komisaruk believes that anorgasmic women could also learn to read and react to their brain activity to try to reach orgasm.

Perhaps more unusual-sounding than orgasmia is the concept of orgasms that have nothing to do with the genitalia at all. Some people can orgasm from being touched in other places on the body, such as the nipples. In this case, researchers believe that the sensations in the nipples are transmitted to the same areas of the brain that receive information from the genitals. However, people have also reported actually feeling orgasms in other parts of their bodies, including their hands and feet. Several people have even described having orgasms in limbs that were no longer there

 One reason may be the layout of the cortical homunculus, a map that shows how different places of the brain's sensory and motor cortices correspond to the organs and limbs of the body. A person who feels an orgasm in a phantom foot, for example, may have experienced a remapping of the senses because the foot is located next to the genitals in the homunculus. The foot is no longer there to provide sensation, so the area for genital sensation took over the space.

Although we now know more about how orgasms impact the brain than ever before, there's still a lot that we don't know. For example, scientists are still debating the evolutionary reason behind the female orgasm. But it's probably safe to say that most people aren't too concerned about the "why" -- they'd prefer to focus on the whos, whats and whens of sex.
 by "environment clean generations"

Minggu, 25 September 2011

A New Study Over Pain



According to a recent Institute of Medicine study, 100 million people in the U.S. suffer from chronic pain: that's about one out of every three people. But how do researchers study this subjective condition in an objective way?

One of the big problems in medicine is the need to rely on participants' self-reports of their experiences. For example, in studying pain, participants may be asked to rank their level of pain on a scale -- and as you might guess, the perception of pain can vary widely between individuals, depending on a person's personal history, heartiness, age, and other factors. What's more, studies have found that there is considerable cultural bias in the diagnosis and treatment of pain, with some patients perceived as fabricating their pain.
But now, researchers say they've come up with an objective way of measuring people's pain levels: by looking into the brain itself to rate pain physiologically.
"We rely on patient self-reporting for pain, and that remains the gold standard," said study author Sean Mackey, M.D., Ph.D. "That's what I, as a physician, rely on when I take care of a patient with chronic pain. But there are a large number of patients, particularly among the very young and the very old, who can't communicate their pain levels. 

Wouldn't it be great if we had a technique that could measure pain physiologically?" After a conference in 2009 on the neuroimaging of pain, Mackey and colleagues were compelled to try to design a "painometer" to measure pain objectively. And this is just what they did.
To begin, the team of researchers brought in eight participants and applied a heat probe to their arms while their brains were being scanned. 

A computer was able to develop a pain algorithm based on what the brain's pain signals looked like when participants were, and were not, experiencing the painful stimulus.
Then, from this algorithm, the computer was "asked" to determine whether pain was being experienced in a new set of subjects with or without the painful stimulus. The computer was right 81 percent of the time -- an impressive number for the painometer version 1.0. The image below shows brain regions that seem to reflect the pain a person experiences.

It is, however, important to remember that this is just a first attempt and there will be kinks to work out. The accuracy rate (81 percent) would likely need to be higher for it to be useful in a clinical setting, and particularly in the legal system. Mackey says that "a key thing to remember is that this approach objectively measured thermal pain in a controlled lab setting. We should take care not to extrapolate these findings to say we can measure and detect pain in all circumstances." More research will certainly help hone the skills of the painometer, which will have numerous applications, and no doubt change the lives of many.
by "environment clean generations"

Images From Brain Transformed Into Digital Videoclips



A year and a half ago, we published a great feature on the current state of the quest to read the human mind. It included some then in-progress work from Jack Gallant, a neuroscientist at U.C. Berkeley, in which Gallant was attempting to reconstruct a video by reading the brain scans of someone who watched that video--essentially pulling experiences directly from someone's brain. Now, Gallant and his team have published a paper on the subject in the journal Current Biology.

This is the first taste we've gotten of what the study actually produces. Here's a video of the reconstruction in action:

 The reconstruction (on the right, obviously) was, according to Gallant, "obtained using only each subject's brain activity and a library of 18 million seconds of random YouTube video that did not include the movies used as stimuli. Brain activity was sampled every one second, and each one-second section of the viewed movie was reconstructed separately."


by "environment clean generations"

Selasa, 20 September 2011

Insulin Spray A Solution Against Alzheimer



A twice-daily dose of insulin, sprayed deep in the nose for easy transit to the brain, may slow or stop the progression of Alzheimer’s disease, according to a new pilot study. The researchers gave 104 patients with mild to moderate Alzheimer’s disease or pre-Alzheimer’s cognitive impairment one of three nasal sprays for four months. One group of patients got a nasal spray with a moderate dose of insulin twice a day, one group got a higher dose, and the third got a squirt of saline solution, as a placebo

The memory, cognitive abilities, and day-to-day functioning of patients given insulin stayed constant or improved slightly—particularly for those given the moderate dose of insulin rather than the high dose—while the abilities and memory of patients given the placebo declined.

It makes sense that insulin might slow the advance of the disease. In addition to its effect on blood sugar levels, insulin seems to guard against some of the ill effects of the  amyloid plaques that build up in the brains of Alzheimer’s patients. Diabetics and other people whose bodies produce too little insulin or aren’t responsive to it are more likely to develop Alzheimer’s.
This was a small, short-term study; to know whether insulin nasal sprays can really keep Alzheimer’s at bay, researchers will need to run longer-lasting studies with more patients. But given that there aren’t currently any ways to treat or slow the course of Alzheimer’s, this study highlights a promising direction for further research.

 by "environment clean generations"

Jumat, 02 September 2011

Transparent Beings No Longer SciFi


Japanese researchers develop a way to turn biological tissue transparent.
All the new breakthroughs in microscopy we’ve seen recently are designed to help scientists see deeper, inside individual cells and into the depths of the brain. Of course, this would be easier to do if there wasn’t a bunch of other tissue blocking the cells you want to see. Japanese researchers have a new solution: Make it all transparent.


A new chemical reagent makes the brain see-through, allowing fluorescent tags to light up neurons and blood vessels deep inside. This enables 3-D images of entire structures, without having to cut anything away or divide anything into smaller sections.

It doesn’t work on living tissue, at least not yet — researchers at RIKEN, Japan’s major research institute, are investigating another, milder reagent that could allow them to study live tissue in this way.


The reagent, called Scale, has specific clarifying properties that do not alter the overall shape or proportion of the sample being washed, according to a news release from RIKEN

First you would have to genetically modify the sample by adding fluorescent proteins to tag certain cells. While it turns the tissue transparent, the Scale method also prevents decreasing the intensity of those fluorescent signals. So once the tissue is washed with Scale, researchers can see the fluorescent proteins flashing.

The fluorescent tags have made it possible to visualize brain regions at a depth of several millimeters, far better than before, and to reconstruct neural networks, RIKEN says. Atsushi Miyawaki and his team at the RIKEN Brain Science Institute have already used it to study neuronal networks among the cerebral cortex, hippocampus and white matter of mouse brains. 

It can work on several other tissues besides the brain, the researchers say — they plan to try Scale on the heart, muscles and kidneys, and on tissues from primate and human biopsy samples.
 Nuclei in the Brain: This image shows nuclei of proliferating neural stem cells (green) and blood vessels (red) tunneling into the transparent hippocampus. The green signal comes from a fluorescent marker.

Still this is almost nothing comparing to what nature does, regarding transparent beings, viz:














by "environment clean generations"


Rabu, 31 Agustus 2011

50 Weird Facts About Human Body



As long as we make efforts to take care of ourselves and live healthy, there is a good chance that our bodies will serve us well for a long time. Our bodies truly are amazing. You might be surprised at what your body is capable of after reading these 50 weird facts about the human body:

The Brain


Complex and poorly understood, the brain is what makes everything work properly. The body may be kept alive, but without the brain, a person can’t truly live. Here are some interesting and weird facts about the brain.


    Brain_090407
  1. The brain doesn’t feel pain: Even though the brain processes pain signals, the brain itself does not actually feel pain.

  2. Your brain has huge oxygen needs: Your brain requires 20 percent of the oxygen and calories your body needs — even though your brain only makes up two percent of your total body weight.

  3. 80% of the brain is water: Instead of being relatively solid, your brain 80% water. This means that it is important that you remain properly hydrated for the sake of your mind.

  4. Your brain comes out to play at night: You’d think that your brain is more active during the day, when the rest of your body is. But it’s not. Your brain is more active when you sleep.

  5. Your brain operates on 10 watts of power: It’s true: The amazing computational power of your brain only requires about 10 watts of power to operate.

  6. A higher I.Q. equals more dreams: The smarter you are, the more you dream. A high I.Q. can also fight mental illness. Some people even believe they are smarter in their dreams than when they are awake.

  7. The brain changes shapes during puberty: Your teenage years do more than just change how you feel; the very structure of your brain changes during the teen years, and it even affects impulsive, risky behavior.

  8. Your brain can store everything: Technically, your brain has the capacity to store everything you experience, see, read or hear. However, the real issue is recall — whether you can access that information.

  9. Information in your brain travels at different speeds: The neurons in your brain are built differently, and information travels along them at different speeds. This is why sometimes you can recall information instantly, and sometimes it takes a little longer.


Your Senses


You might be surprised at the amazing things your various senses can accomplish.

    Nose
  1. Your smell is unique: Your body odor is unique to you — unless you have an identical twin. Even babies recognize the individual scents of their mothers.

  2. Humans use echolocation: Humans can use sound to sense objects in their area using echolocation. It is thought that those who are blind develop this ability to heightened effectiveness.

  3. Adrenaline gives you super strength: Yes, with the proper response in certain situations, you really can lift a car.

  4. Women smell better than men: Women are better than men at identifying smells.

  5. Your nose remembers 50,000 scents: It is possible for your nose to identify and remember more than 50,000 smells.

  6. Your hearing decreases when you overeat: When you eat too much food, it actually reduces your ability to hear. So consider eating healthy — and only until you are full.

  7. Your sense of time is in your head: How you experience time is all about your perception. Some speculate that stress can help you experience time dilation. Apparently, time manipulation isn’t just for superheroes.

Reproduction


How we as a species reproduce offers all sorts of interesting weird facts. Here are some of the weirder things you might not know.

    Views_of_a_Foetus_in_the_Womb_detail
  1. Your teeth are growing before birth: Even though it takes months after you are born to see teeth, they start growing about six months before you are born.

  2. Babies are stronger than oxen: On a pound for pound basis, that is. For their size, babies are quite powerful and strong.

  3. Babies always have blue eyes when they are born: Melanin and exposure to ultraviolet light are needed to bring out the true color of babies’ eyes. Until then they all have blue eyes.

  4. Women might be intrinsically bi: There are sex studies that indicate that women might bisexual intrinsically, no matter how they class themselves, while men are usually either gay or straight.

  5. Most men have regular erections while asleep: Every hour to hour and a half, sleeping men have erections — though they may not be aware of it.

  6. Sex can be a pain reliever: Even though the “headache” excuse is often used to avoid sex, the truth is that intercourse can provide pain relief. Sex can also help you reduce stress.

  7. Chocolate is better than sex: In some studies, women claim they would rather have chocolate than sex. But does it really cause orgasm? Probably not on its own.


Body Functions


The things our bodies do are often strange and sometimes gross. Here are some weird facts about the way your body functions.

    800px-Sneeze
  1. Earwax is necessary: If you want healthy ears, you need some earwax in there.

  2. Your feet can produce a pint of sweat a day: There are 500,000 (250,000 for each) sweat glands in your feet, and that can mean a great deal of stinky sweat.

  3. Throughout your life, the amount of saliva you have could fill two swimming pools: Since saliva is a vital part of digestion, it is little surprise that your mouth makes so much of it.

  4. A full bladder is about the size of a soft ball: When your bladder is full, holding up to 800 cc of fluid, it is large enough to be noticeable.

  5. You probably pass gas 14 times a day: On average, you will expel flatulence several times as part of digestion.

  6. A sneeze can exceed 100 mph: When a sneeze leaves your body, it does so at high speeds — so you should avoid suppressing it and causing damage to your body.

  7. Coughs leave at 60 mph: A cough is much less dangerous, leaving the body at 60 mph. That’s still highway speed, though.

 

Musculoskeletal System


Find out what you didn’t know about your muscles and bones.

    skeleton
  1. Bones can self-destruct: It is possible for your bones to destruct without enough calcium intake.

  2. You are taller in the morning: Throughout the day, the cartilage between your bones is compressed, making you about 1 cm shorter by day’s end.

  3. 1/4 of your bones are in your feet: There are 26 bones in each foot, meaning that the 52 bones in account for 25 percent of your body’s 206 bones.

  4. It takes more muscles to frown than to smile: Scientists can’t agree on the exact number, but more muscles are required to frown than to smile.

  5. When you take a step, you are using up to 200 muscles: Walking uses a great deal of muscle power — especially if you take your 10,000 steps.

  6. Your tongue is the strongest muscle in your body: Compared to its size, the tongue is the strongest muscle. But I doubt you’ll be lifting weights with it.

  7. Bone can be stronger than steel: Once again, this is a pound for pound comparison, since steel is denser and has a higher tensile strength.


Unnecessary Body Parts


We have a number of body parts that are, well, useless. Here are some facts about the body parts we don’t actually need.

    800px-Toes
  1. Coccyx: This collection of fused vertebrae have no purpose these days, although scientists believe it’s what’s left of the mammal tail humans used to have. It may be useless, but when you break your coccyx, it’s still painful.

  2. Pinkie toe: There is speculation that since we no longer have to run for our dinner, and we wear sneakers, the pinkie toe‘s evolutionary purpose is disappearing — and maybe the pinkie itself will go the way of the dodo.

  3. Wisdom teeth: This third set of molars is largely useless, doing little beyond crowding the mouth and sometimes causing pain.

  4. Vomeronasal organ: There are tiny (and useless) chemoreceptors lining the inside of the nose.

  5. Most body hair: While facial hair serves some purposes, the hair found on the rest of body is practically useless and can be removed with few ill effects.

  6. Female vas deferens: A cluster of dead end tubules near the ovaries are the remains of what could have turned into sperm ducts.

  7. Male Uterus: Yeah, men have one too — sort of. The remains of this undeveloped female reproductive organ hangs on one side of the male prostate gland

  8. Appendix: Yep, your appendix is basically useless. While it does produce some white blood cells, most people are fine with an appendectomy.


Random Weird Body Facts


Here are a few final weird facts about the human body.

    Psoriasis_of_the_palms
  1. Your head creates inner noises: It’s rare, but exploding head syndrome exists.

  2. Memory is affected by body position: Where you are and how you are placed in your environment triggers memory.

  3. You can’t tickle yourself: Go ahead. Try to tickle yourself.

  4. Being right-handed can prolong your life: If you’re right-handed, you could live up to nine years longer than a lefty.

  5. Only humans shed emotional tears: Every other animal that produces tears has a physiological reason for doing so.



by "environment clean generations"